منابع مشابه
Toroidal proteins: Running rings around DNA
Recent structural data indicate that the toroidal form is quite common among DNA-binding enzymes. Is this abundance of ring-shaped proteins a coincidence, or does it reflect convergence to a winning quaternary structure?
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Helicases are active in many aspects of DNA replication, recombination, repair and transcription. An integral membrane bacterial protein assembly involved in the transfer of DNA between cells has been shown to resemble a ring helicase, suggesting that it hydrolyzes ATP to pump DNA through a central channel.
متن کاملJoan Brugge: Running rings around cancer
JCB • VOLUME 189 • NUMBER 6 • 2010 922 J oan Brugge was an undergraduate at Northwestern University when her sister was diagnosed with a brain tumor. Her sister’s doctors couldn’t say what caused the disease; they speculated that a virus might be involved. This spurred Brugge’s lifelong quest to learn about the causes of cancer, starting with the study of tumor viruses (1). Brugge identifi ed t...
متن کاملDNA Polymerase III: Running Rings around the Fork
within 30–40 min, RNA primers are generated on the Metabolic processes are often orchestrated by the coorlagging strand template every 1–2 s at average intervals dinated action of multiple protein components. Because of 1–2 kb. The elongationof each primer by pol III holoenof the complexity of such enzymatic mechanisms, the zyme takes place at a rate of about 1000 nucleotides participant protei...
متن کاملRings of controversy around benzene.
FLOW-CYTOMETRIC MEASUREMENTS of cell DNA content or narrow-angle light scatter (NLS) can provide a basis for discriminating neoplastic from non-neoplastic cells by identifying differences in DNA content and cell size. Flow-cytometric analyses of many human neoplasms have been previously reported (Barlogie et at., 977, 1978) showing aneuploidy in 80-90% of non-lymphoid solid tumours and 4060% of...
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ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2014
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.2027